Monthly Archives:: September 2012

Design help for drug cocktails for HIV patients: Mathematical model helps design efficient multi-drug therapies

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For years, doctors treating those with HIV have recognized a relationship between how faithfully patients take the drugs they prescribe, and how likely the virus is to develop drug resistance. New research is helping to explain why those differences exist, and may help doctors quickly and cheaply design new combinations of drugs that are less likely to result in resistance.

Anti-HIV drug simulation offers ‘realistic’ tool to predict drug resistance and viral mutation

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Pooling data from thousands of tests of the antiviral activity of more than 20 commonly used anti-HIV drugs, AIDS experts have developed what they say is the first accurate computer simulation to explain drug effects. Already, the model clarifies how and why some treatment regimens fail in some patients who lack evidence of drug resistance.

Can’t smell anything? Discovery may give you hope

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Scientists have restored the sense of smell in mice through gene therapy for the first time -- a hopeful sign for people who can’t smell anything from birth or lose it due to disease. The achievement in curing congenital anosmia may also aid research on other conditions that also stem from problems with the cilia.

Anti-clotting therapy may be used too often following orthopaedic surgery or trauma

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Men and women who undergo joint replacement procedures, as well as those who have significant fractures, tend to be at an increased risk of developing pulmonary emboli (PE), blood clots that travel to the lungs where they may cause serious complications and even death. Patients are often aggressively treated with anticoagulants, or blood thinners, to help prevent the clots from forming, but a new study indicates that some blood clots being identified by today's sensitive testing methods may not require aggressive treatments.

Flying high: Researchers decipher manic gene

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Flying high, or down in the dumps -- individuals suffering from bipolar dis­order alternate between depressive and manic episodes. Re­searchers have now discovered, based on patient data and animal models, how the NCAN gene results in the manic symptoms of bipolar disorder.
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