Biophysicists unravel secrets of genetic switch

Posted August 30th, 2012 by PCC STEM & filed under Biology, News.

Biophysicists have experimentally demonstrated, for the first time, how the nonspecific binding of a protein known as the lambda repressor, or C1 protein, bends DNA and helps it close a loop that switches off virulence. Findings are the first direct and quantitative determination of non-specific binding and compaction of DNA, relevant for the understanding of DNA physiology, and the dynamic characteristics of an on-off switch for the expression of genes.

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